Indications and Usage for Victoza® (liraglutide [rDNA origin] injection)
Victoza® (liraglutide [rDNA origin] injection) is an injectable prescription
medicine that may improve blood sugar (glucose) in adults with type 2 diabetes when
used along with diet and exercise.
Victoza® is not recommended as the first medication
to treat diabetes. Victoza® has not been studied
in patients with history of inflammation of the pancreas (pancreatitis). Victoza® is not a substitute for insulin and has not been
studied in combination with prandial (mealtime) insulin. Victoza®
is not for people with type 1 diabetes or people with diabetic ketoacidosis. It
is not known if Victoza® is safe and effective in
children. Victoza® is not recommended for use in
Important Safety Information
In animal studies, Victoza® caused thyroid tumors—including thyroid
cancer—in some rats and mice. It is not known whether Victoza® causes
thyroid tumors or a type of thyroid cancer called medullary thyroid cancer (MTC)
in people, which may be fatal if not detected and treated early. Do not use Victoza®
if you or any of your family members have a history of MTC or if you have Multiple
Endocrine Neoplasia syndrome type 2 (MEN 2). While taking Victoza®,
tell your doctor if you get a lump or swelling in your neck, hoarseness, trouble
swallowing, or shortness of breath. These may be symptoms of thyroid cancer.
Do not use Victoza® if you are allergic to liraglutide or any of the ingredients
in Victoza®. Serious allergic reactions can happen with Victoza®. If symptoms of
serious allergic reactions occur, stop taking Victoza® and seek medical attention.
Pancreatitis may be severe and lead to death. Before taking Victoza®, tell your
doctor if you have had pancreatitis, gallstones, a history of alcoholism, or high
blood triglyceride levels since these medical conditions make you more likely to
Stop taking Victoza® and call your doctor right away if you have
pain in your stomach area that is severe and will not go away, occurs with or without
vomiting, or is felt going from your stomach area through to your back. These may
be symptoms of pancreatitis.
Before using Victoza®, tell your doctor about all the medicines you
take, especially sulfonylurea medicines or insulin, as taking them with Victoza®
may affect how each medicine works. If you use Victoza® with insulin,
you may give both injections in the same body area (for example, your stomach area),
but not right next to each other.
Also tell your doctor if you have severe stomach problems such as slowed emptying
of your stomach (gastroparesis) or problems with digesting food; have or have had
kidney or liver problems; have any other medical conditions; or are pregnant or
plan to become pregnant. Tell your doctor if you are breastfeeding or plan to breastfeed.
It is unknown if Victoza® will harm your unborn baby or if Victoza®
passes into your breast milk.
Your risk for getting hypoglycemia, or low blood sugar, is higher if you take Victoza®
with another medicine that can cause low blood sugar, such as a sulfonylurea or
insulin. The dose of your sulfonylurea medicine or insulin may need to be lowered
while taking Victoza®.
Victoza® may cause nausea, vomiting, or diarrhea leading to dehydration,
which may cause kidney failure. This can happen in people who have never had kidney
problems before. Drinking plenty of fluids may reduce your chance of dehydration.
The most common side effects with Victoza® include headache, nausea,
and diarrhea. Nausea is most common when first starting Victoza®,
but decreases over time in most people. Immune system related reactions, including
hives, were more common in people treated with Victoza® compared
to people treated with other diabetes drugs in medical studies.